Author

Hong-Li Yin

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Open access Jul 2026

An Integrated Transcriptional and Post-Transcriptional Regulatory Circuit Orchestrated by NUDT21 Maintains the Proliferation and Survival of Neuroblastoma.

BACKGROUND Neuroblastoma (NB) is the most prevalent pediatric solid tumor, associated with a poor prognosis. While alternative polyadenylation (APA) is a key post-transcriptional regulatory mechanism in many cancers, its role in NB remains largely unexplored. METHODS We used public expression profiles from NB and nor...

Yang Yang, Chunxia Shi, Jian-Wei Wang et al. · Neuro-Oncology · 0 citations

Open access Aug 2026

Virtual screening and MD simulation-guided discovery of CDK12-IN-3, a potent ALK inhibitor suppressing neuroblastoma growth in vitro and in vivo

CDK12-IN-3 is validated as a novel selective ALK inhibitor with potent anti-NB activity, providing a promising lead compound and an efficient dynamic simulation-guided drug repurposing paradigm for overcoming ALK inhibitor resistance in high-risk NB.

Tianyi Liu, Xuejiao Hu, Wenxin Yan et al. · Frontiers in Chemistry · 0 citations