Hong-Mei Zhang

Tumor-Associated Immunosenescence: Mechanisms, Biomarkers, and Age-Adaptive Immunotherapy.

Immunosenescence alters immune-cell composition, signaling, metabolism, and regenerative capacity, but chronological age alone does not reliably predict response to cancer immunotherapy. In older adults, thymic involution, hematopoietic remodeling, inflammaging, and the accumulation of dysfunctional lymphoid and myeloi...