Hongmin Cai

Morphology-Aware Implicit Super-Resolution Network for Pathological Images

Accurate diagnosis in Digital Pathology (DP) relies on high-resolution whole-slide images, yet clinical deployment is often limited by hardware costs. Super-Resolution (SR) offers a promising alternative by computationally enhancing low-resolution acquisitions. However, existing SR methods frequently struggle to preser...

URFPert: Unrolled Regulatory Flow Network for Out-of-Distribution Single-Cell Perturbation Prediction

URFPert: Unrolled Regulatory Flow Networks for Out-of-Distribution Single-Cell Perturbation Prediction

Single-cell perturbation screens enable systematic discovery of gene regulatory mechanisms, yet the exponential expansion of perturbation space makes comprehensive experimentation impractical. Although in silico predictors have been increasingly proposed to address this challenge, most existing methods either assume st...

DeMixPert: Decomposed Response Modeling with Gaussian Mixtures for OOD Single-Cell Perturbation Prediction

Predicting transcriptome-wide responses to unseen genetic perturbations remains a major computational challenge because accurate prediction requires recovering both perturbation-specific transcriptional shifts and heterogeneous cellular responses. Existing methods often entangle deterministic response structure with st...

CHM-Net: Center Heatmap-driven Macro-Micro Modeling Network for MRI-based Microbial Density Stratification

This work investigates MRI-based Microbial Density Stratification as a patient-level representation learning task, and Center Heatmap-driven Macro-micro modeling Network (CHM-Net) is introduced for this task, establishing the link between imaging phenotypes and microbial states through center heatmap-guided small-lesio...