Dual MDM2 and PPARG regulatory axes mediate the antiepileptic effects of Gouteng: An Integration of Bioinformatics, Network Pharmacology, Machine Learning, Molecular Docking, and MD Simulations.
Gouteng is a traditional Chinese medicine widely used for the clinical treatment of epilepsy, yet the specific mechanism underlying its antiepileptic has not been elucidated. Network pharmacology, bioinformatics, machine learning, molecular docking, MD simulation, and ADMET druggability analysis were performed to syste...