Matrine induces aggressive prostate cancer cell death via inhibition of PPARα activity: insights from transcriptomics, molecular docking, and functional studies.
BACKGROUND Prostate cancer remains a significant global health burden with limited treatment options for advanced stages. Matrine, a natural alkaloid from Sophora flavescens, has demonstrated anti-cancer potential. This study aimed to investigate its efficacy against aggressive prostate cancer cell death and elucidate...