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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Hong-Tu Hu

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3 papers indexed here

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Review Aug 2026

Drug failure in diabetic kidney disease: translational barriers, target validation and trial de-risking strategies.

Diabetic kidney disease (DKD) remains a difficult therapeutic setting in nephrology, metabolism and clinical pharmacology. Standard care has moved from glucose- and blood-pressure-centred treatment toward disease-modifying therapy built around renin-angiotensin-aldosterone system (RAAS) blockade, sodium-glucose cotrans...

Hong-Tu Hu, Suyue Hou, Wen-Jie Chen et al. · 0 citations
Oct 2026

SIRT3 regulates GLS1 K311 acetylation to restrain glutamate-driven ferroptosis in renal fibrosis.

Renal tubulointerstitial fibrosis is a final common pathway of chronic kidney disease (CKD), but the metabolic mechanisms linking mitochondrial dysfunction to ferroptotic tubular injury remain incompletely defined. We found that a SIRT3-GLS1-glutamate-p53/SLC7A11 pathway links mitochondrial deacetylation to ferroptosis...

Miao Yan, Hong-Tu Hu, Cheng Chen et al. · 0 citations
Review Open access Aug 2026

Hallmarks of acute kidney injury: molecular endotypes, precision phenotyping, and phase-adapted therapy

Summary Acute kidney injury (AKI) is a heterogeneous syndrome for which creatinine and urine output incompletely represent underlying biology and temporal evolution. We organise AKI pathophysiology into four interconnected dimensions: initiation and effector injury; cell fate and immune microenvironment; repair and out...

Hong-Tu Hu, Zi-Kang Liu, Rui Ji et al. · 1 citation

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