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Author

Hong-Wei Hou

3 papers indexed here

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Open access Sep 2026

Spatially Resolved Multi-Omics Reveals Brain–Kidney Compartmentalization and Region-Specific Molecular Reprogramming After Acute Nicotine Exposure

Background: Traditional bulk tissue analyses obscure the precise spatial compartmentalization of nicotine and its molecular effects within individual anatomical regions. This study aimed to develop and apply a high-resolution spatial multi-omics framework to characterize the localized disposition and functional respons...

Qian Li, Lu-Tao Xu, Ming-Yu Zhu et al. · 0 citations
Open access Sep 2026

Single-cell transcriptomics reveals distinct microglial state remodeling associated with the (R)-nicotine/diosmetin combination and galantamine in LPS-challenged BV2 cells

It is indicated that the DR condition was associated with remodeling of LPS-challenged BV2 microglial-like states, attenuation of inflammatory programs, and increased neurotrophic outputs relative to LPS, without significantly reducing CCK-8-assessed metabolic activity.

Yi-Han Liu, Hao Yu, Jing-Bin Zhang et al. · 0 citations
Aug 2026

A Novel Protein Corona-Based Secretome Profiling Assisting Cell Multiomics Analysis

Multiomics analysis integrates complementary molecular layers to decode biological complexity; however, the secretome, representing the extracellular and dynamic response of cellular function, remains largely absent from existing multiomics frameworks. Secretome profiling has been constrained by high background inter...

Cai-Wei Hu, Jia-Liang Zhao, Qian Li et al. · 0 citations

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