A tetrahedral DNA nanostructure-based DNAzyme fluorescent nanoprobe for intracellular Mn2+ imaging.
Manganese (Mn) is an essential trace element in human body and acts as an enzyme cofactor, a neurotoxicant, and an activator of the cGAS-STING pathway. Monitoring intracellular Mn2+ is critical yet challenging due to its weak ligand-binding affinity and paramagnetic quenching effect. Here, we report a fluorescent nanop...