Open access
Sep 2026
Degradomic and Transcriptomic Profiling Reveals Pleiotropic Roles of Extracellular Granzyme B in Scarring and Fibrosis.
Granzyme B (GzmB) is a serine protease traditionally recognized for its role in lymphocyte-mediated apoptosis. In specific conditions, GzmB accumulates in the extracellular milieu and retains its proteolytic activity, cleaving extracellular proteins thereby contributing to disease progression. Nevertheless, pathologica...
A. Aubert, A. Prudova, Jeffrey S. Tang et al.
· Matrix Biology · 0 citations