Author

Hong-Ye Wang

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Oct 2026

BAZ2A-induced epigenetic states in cancer cells fuel palmitate accumulation in the tumor microenvironment driving CAR-T cell exhaustion.

Hong-Ye Wang, Hai-Gang Geng, Jing-Tong Zhao et al. · Nature Cancer · 0 citations

Open access Sep 2026

Single-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance.

An FAP/TREM2-targeting bispecific antibody is developed to disrupt this spatial nexus and restore therapeutic sensitivity in MDR patient-derived xenograft models with favorable safety.

K. Shen, Lu Wang, Zi-Xu Gao et al. · Cell Reports Medicine · 0 citations

Open access Jul 2026

Manufacturing and electrostatic surface optimization of CAR-T cells improve therapeutic efficacy in liver malignancies.

Systematic optimization of manufacturing conditions and structure-based charge engineering of CAR constructs synergistically enhance therapeutic efficacy against liver malignancies, providing a translatable framework for improving solid tumor CAR-T therapy.

Linke Bian, Jiufei Zhu, Hong-Ye Wang et al. · Hepatology Communications · 0 citations