Human umbilical cord-derived mesenchymal stem cells ameliorate muscle dysfunction and metabolic dysregulation in the CuZnSOD null mouse model of sarcopenia.
These findings demonstrate that UC-MSCs function as context-dependent metabolic modulators, alleviating oxidative stress-induced sarcopenia through attenuation of oxidative stress, restoration of systemic IGF-1, and selective reprogramming of lipid metabolism, while dynamically adjusting energy metabolism in physiologi...