Author

Hong-Yu Chen

2 papers indexed here

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Open access Sep 2026

Highly efficient intranasal H5N1 vaccine based on a safe vesicular stomatitis virus (VSV) vector

Recombinant vesicular stomatitis virus (rVSV) is an increasingly popular vaccine vector, but it still faces challenges such as difficulties in construction, low in vitro amplification titers, safety concerns, and uncertain mucosal immune effects. Therefore, there is an urgent need to construct new VSV vectors for next-...

Ziteng Liang, Meng-Yi Zhang, Jie Zhang et al. · Signal Transduction and Targ... · 0 citations

Open access Sep 2026

A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges

The continued antigenic evolution of SARS-CoV-2 Omicron subvariants has progressively eroded vaccine-elicited protective immunity, driving demand for next-generation candidates that confer broad-spectrum protection against phylogenetically divergent strains. Here we report the design and preclinical evaluation of SV, a...

Jia-Li Xu, Rui Peng, Long-Hai Yuan et al. · Molecular Biomedicine · 0 citations