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Author

Hong-Yu Ma

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Open access Oct 2026

NKG2D overexpression potentiates CAR-T cells through costimulation by tumor NKG2D ligands.

Chimeric antigen receptor (CAR)-T cell therapy has achieved remarkable success in hematologic malignancies, but durable efficacy remains limited by insufficient CAR-T cell persistence. Here, we show that activated CAR-T cells upregulate multiple NKG2D ligands (NKG2DLs), increasing their susceptibility to natural killer...

Jia-Jia Li, Lu Han, Qi Zhu et al. · 0 citations

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