Hong-Zhen Jin

Targeting heparanase-associated epithelial glycocalyx remodeling attenuates Akt/NF-κB–related barrier dysfunction in experimental COPD

Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation, epithelial barrier dysfunction, and progressive structural remodeling. Although glycocalyx impairment has been implicated in COPD pathogenesis, the mechanisms linking glycocalyx degradation to epithelial barrier...