Wool Keratin-Engineered Manganese Nanozyme with Tumor Microenvironment-Adaptive Self-Cascade Capability for Hepatocellular Carcinoma Therapy.
This work establishes the first wool keratin-guided Mn3O4 nanozymes (MnWK) with self-cascade catalytic capability that systematically transforms the TME into a pro-oxidative microenvironment, achieving high therapeutic efficacy through synergistic hypoxia alleviation and ROS-mediated apoptosis.