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Hongmei Xie

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Open access Aug 2026

Dual Targeting of EGFR and HER2 by a Bispecific Antibody-Drug Conjugate Demonstrates Broad Antitumor Activity in Multiple Solid Tumors.

While HER2-directed antibody-drug conjugates (ADCs), such as ENHERTU® (DS-8201), represent a major therapeutic advance, treatment options for tumors with low HER2 expression remain limited, and acquired resistance continues to pose a significant clinical challenge. Given the frequent co-expression of EGFR and HER2 acro...

Xiaojuan Chai, Fu Li, Hongmei Xie et al. · 0 citations
Open access Jul 2026

DEHP exposure induces cholesterol dysregulation and inflammatory signaling in human colonic epithelial cells: Implications for early colorectal carcinogenesis.

Di(2-ethylhexyl) phthalate (DEHP), a ubiquitous plasticizer and a classified Group 2B carcinogen, is associated with increased colorectal cancer (CRC) incidence, but its causal role and mechanisms are unclear. We investigated DEHP toxicity in human colonic epithelial cells (NCM460) using an integrated multi-omics appro...

Xinrui Zhou, Jiayi Diao, Jiamin Lu et al. · 0 citations

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