Author

Hongye Wang

2 papers indexed here

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Open access Sep 2026

Single-cell and spatial multi-omics reveal a recurrent multicellular niche at the tumor-stroma interface in multidrug resistance.

Multi-drug resistance (MDR) is an almost inevitable endpoint of cancer therapy, driving rapid tumor progression, yet its evolutionary logic remains unclear because MDR tumors are rarely resected. Using paired therapy-naive and MDR melanoma specimens from a clinical trial, integrated with single-cell and spatial multi-o...

K. Shen, Lu Wang, Zi-Xu Gao et al. · Cell Reports Medicine · 0 citations

Open access Jul 2026

Manufacturing and electrostatic surface optimization of CAR-T cells improve therapeutic efficacy in liver malignancies.

Systematic optimization of manufacturing conditions and structure-based charge engineering of CAR constructs synergistically enhance therapeutic efficacy against liver malignancies, providing a translatable framework for improving solid tumor CAR-T therapy.

Linke Bian, Jiufei Zhu, Hong-Ye Wang et al. · Hepatology Communications · 0 citations