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Author

Hongyun Wang

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Open access Jul 2026

Dual-Target Inhibition of CDK5 and PBK in Pituitary Neuroendocrine Tumors: Mechanisms and Therapeutic Potential

The CDK5-PBK mutual phosphorylation axis serves as a key driver of invasiveness in PitNETs and proguanil hydrochloride represents a promising candidate dual-target therapeutic agent capable of disrupting this pathway to suppress tumor growth.

Jinghao Jin, Zhaoyi Yi, Hong-Yun Wang et al. · 0 citations

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