A covalent pan-coronaviral inhibitor that targets 19 Mpros across the α, β, γ, and δ genera, encompassing bat, human, and other animal coronaviruses, AVI8122 exhibits low nanomolar potency and favorable pharmacokinetics in mice and is positioned as an early lead compound and a tractable structural starting point for th...
Pu Chen, Ulrike Strunk, E. Arutyunova et al.· Journal of Medicinal Chemist...· 0 citations
CD-nMS is established, alone or in combination with SLOMO, as a broadly applicable assay for quantitative characterization of complex biomolecular interactions across soluble, glycosylated, and membrane-associated systems.
Ziyu Zhang, D. Bui, Ling Han et al.· Analytical Chemistry· 0 citations
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