Long-Term Biostimulatory Efficacy of Polycaprolactone Facial Fillers: A Two-Year Quantitative Assessment of Neocollagenesis Using Second-Harmonic Generation Microscopy.
BACKGROUND Polycaprolactone (PCL) microsphere-based facial fillers are used for aesthetic enhancements but understanding their long-term biostimulatory efficacy in inducing neocollagenesis requires precise, quantitative structural evaluation. OBJECTIVES To investigate and quantitatively assess the long-term efficacy...