Author

Hsien-Yuan Chang

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Open access Aug 2026

Outcome evaluation of percutaneous coronary intervention vs medical therapy alone in patients with chronic coronary syndrome

This study provides real-world evidence by comparing the long-term clinical outcomes of percutaneous coronary intervention (PCI) versus medical therapy alone in patients with chronic coronary syndrome (CCS) diagnosed non-invasively, given the lack of evidence in this population. This retrospective cohort study (2013–20...

Hsien-Yuan Chang, Hsin-Yu Fang, Mu-Shiang Huang et al. · Journal of Food and Drug Ana... · 0 citations

Aug 2026

Vincristine enhances doxorubicin cardiotoxicity in human iPSC-derived cardiomyocytes: Partial attenuation by SGLT2 inhibition.

BACKGROUND Doxorubicin is a well-known cardiotoxic chemotherapeutic agent. Whether its combination with vincristine exacerbates cardiotoxicity and the underlying mechanisms remains unclear. METHODS Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) were treated with doxorubicin, vincristine, or bot...

Hsien-Yuan Chang, Hsiao-Chu Hsu, Yi-Hsien Fang et al. · Toxicology and Applied Pharm... · 0 citations