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Hsuan-Ai Chen

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Open access Jul 2026

A magic methyl effect in the active site of a methyltransferase ribozyme

This work pinpointed how 2’-O-methylation of active site nucleotides synergistically enhance ribozyme activity by reducing ribose rings’ conformational flexibility by reducing ribose rings’ conformational flexibility.

Jana Aupič, Hsuan-Ai Chen, Carolin P. M. Scheitl et al. · 0 citations

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