Hu Lei

Targeting USP47 reprograms macrophage polarization to ameliorate septic peritonitis and promote cutaneous wound healing

Roles of JAMM-family deubiquitinase STAMBPL1 in cellular homeostasis and human cancer

Ubiquitin-specific protease 48: Molecular mechanisms, pathophysiological roles and therapeutic potential.

Current advances in USP48 structure, substrate specificity, molecular mechanisms, and disease-specific functions are synthesized to provide a critical evaluation of preclinical USP48-targeted therapeutic strategies, and delineate the major conceptual and translational challenges impeding the clinical development of USP...

Identification of YL064 as a novel inhibitor of ATXN3 to suppress tumor growth and metastasis by promoting degradation of oncogenic substrates

YL064 is established as a promising ATXN3 inhibitor that targets the ubiquitin-proteasome pathway to exert anti-tumor effects, highlighting its potential as a novel therapeutic agent for ATXN3-driven cancers.

USP2 in cancer: a double-edged sword and therapeutic target.

This review systematically synthesizes the mechanistic roles of USP2 across various cancers, highlighting its function as a double-edged sword, and comprehensively evaluates the landscape of emerging USP2 inhibitors.