Venetoclax-based regimens have become increasingly integrated into the therapeutic landscape of acute myeloid leukemia (AML), yet primary resistance and relapses remain major barriers to durable benefits. Building on our previous discovery of CD84 as a critical survivor and redox regulator in AML, we here demonstrate t...
Functional analysis demonstrates that DHX15R222G cooperates with AML1-ETO fusion protein to enhance AML leukemia stem cell (LSC) activity and promote resistance to standard chemotherapy, and underscores the pivotal role of oncogenic DHX15 mutations in regulating AML LSC activity.
Qi-Long Li, Pei-Qi Xing, Jin Xu et al.· Leukemia· 0 citations
Using mRNA sequencing, two novel fusion genes are identified and validated and it is proposed that the combination of these novel fusion genes, multiple SNVs, and the complex karyotype collectively contributed to the patient’s multidrug resistance.
Jifang Tu, Yungui Wang, Xiangli Gao et al.· Therapeutic Advances in Hema...· 0 citations
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