A pseudoenzyme sensor of trehalose-6-phosphate directly represses the metabolic integrator SnRK1 in plants.
Trehalose-6-phosphate (T6P) is a central metabolic signal linking sugar availability to plant growth, carbon utilization, and productivity, yet its sensing and signaling mechanisms remain elusive. Using chemical biology and functional approaches, we identify the noncatalytic pseudoenzyme Class-II T6P synthase (TPS-II)...