Author

Hua-Ke Jiang

2 papers indexed here

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Open access Oct 2026

ANGPTL8 induces the aging of hematopoietic stem/progenitor cells

Hematopoiesis depends on the sustained function of hematopoietic stem and progenitor cells (HSPCs). However, aging progressively impairs HSPC function, contributing to immunosenescence, hematologic malignancies, and degenerative disorders. Therefore, elucidating the mechanisms underlying HSPC aging is essential for dev...

Mei-Juan Chen, Min Zhang, Han-Yi Mei et al. · Biogerontology (Dordrecht) · 0 citations

Open access Sep 2026

Trimethylamine N-oxide promotes lymphoid differentiation of hematopoietic stem and progenitor cells.

BACKGROUND Persistent lymphopenia represents a clinically relevant adverse effect associated with radiotherapy, surgery and infection and is linked to unfavorable clinical outcomes. Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite generated from dietary choline and L-carnitine, has emerged as a potent...

Min Zhang, Han-Yi Mei, Xin-Yu Bai et al. · Molecular Immunology · 0 citations