Author

Hua Li

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Open access Sep 2026

PROTAC probe-assisted degradomics identifies SPINT2 as a candidate cellular target involved in the anti-cancer activity of Flupentixol.

Targeted protein degradation has emerged not only as a therapeutic modality but also as a useful strategy for target deconvolution. This study investigated the anti-cancer activity and pharmacological targets of the anti-psychotic drug Flupentixol using a PROTAC probe-assisted degradomics strategy. We first verified th...

Ming-Yue Lv, Qing-Yuan Hu, Jing-Kai Liang et al. · Bioorganic chemistry (Print) · 0 citations

Open access Sep 2026

The molecular basis of ADP-ribose pyrophosphorylation by a phage PRPS-like enzyme in NAD+ reconstitution

Abstract Depletion of cellular NAD+ is an increasingly recognized bacterial antiphage strategy, and many phages counter this pressure by rebuilding NAD+ from its cleavage products. In the NARP1 pathway, Adps converts ADP-ribose (ADPR) and ATP into ADPR-PP, the immediate substrate for Namat-dependent NAD+ synthesis, but...

Meng-Xi Liu, Jing-Bo Ma, Qing-Qing Zhang et al. · Nucleic Acids Research · 0 citations