Author

Hua-Li Zhang

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Sep 2026

HSF1 Protects Against Sepsis by Transcriptionally Upregulating Neutrophil C5aR1 to Enhance Antimicrobial Defense.

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The resulting septic shock and multiple organ dysfunction syndrome (MODS) are the primary drivers of mortality. Heat shock factor 1 (HSF1), a master transcription factor regulating cellular stress responses, has been sho...

Kai-Yuan Song, Si-Chuang Tan, Nian Wang et al. · Shock · 0 citations

Open access Sep 2026

NINJ1 Defines a Hyperinflammatory Monocyte State Associated with Severe COVID-19

Background/Objectives: Severe coronavirus disease 2019 (COVID-19) is characterized by dysregulated immune activation and excessive inflammation; however, the specific immune cell states that drive disease progression remain incompletely understood. Methods: Here, we integrated single-cell RNA sequencing analysis of per...

Fang Yu, Hao Ma, Mu-Yuan Li et al. · Biomedicines · 0 citations

Aug 2026

IL1R2⁺ Inflammatory Monocytes Contribute to Immune Dysregulation and Predict Mortality in COVID-19.

IL1R2 identifies a highly inflammatory monocyte state associated with COVID-19 immune dysregulation, supporting its potential role as a complementary prognostic biomarker and therapeutic target.

Yi-Ying Yang, Fang Yu, Mu-Yuan Li et al. · Shock · 0 citations