Author

Hua-Long Chen

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Review Open access Sep 2026

Current Landscape of Glycogen Synthase Kinase-3β PET Tracers: Progress, Limitations, and Perspectives—A Narrative Review

Background/Objectives: Glycogen synthase kinase-3β (GSK-3β) serves as a crucial molecular target for Alzheimer’s disease and other neurological disorders. Positron emission tomography (PET) enables non-invasive quantification of GSK-3β in vivo, offering value for early diagnosis and mechanistic studies. However, despit...

Hua-Long Chen, Lu Zhang, Bing-Ke Jiao et al. · Pharmaceuticals · 0 citations

Sep 2026

First-In-Human PET Imaging of Synaptic Vesicle Glycoprotein 2A with [18F]BIBD-181: Automation, Biodistribution, Dosimetry, and Preliminary Application in Epilepsy

In pilot epilepsy patients, [18F]BIBD-181 positron emission tomography results revealed focal SV2A reductions that were confined to the epileptogenic lesions, suggesting that SV2A imaging may offer more precise lesion delineation, particularly when [18F]FDG abnormalities extend beyond the true epileptogenic zone.

Z. Qiao, Shen Li, Yong-Zhong Zhang et al. · Molecular Pharmaceutics · 0 citations