Open access
Aug 2026
Dose-dependent exercise promotes the transition from atrial protection to arrhythmogenic vulnerability: the intermediary role of calcium handling instability in substrate remodeling
Background Endurance athletes carry an elevated risk of atrial fibrillation (AF), yet the exercise dose threshold at which physiological cardiac adaptation gives way to maladaptive remodeling, and the potential involvement of calcium (Ca2+) handling in this transition, remain poorly delineated. Methods and results C57B...
Shu-Wei Suo, Xiao-Lin Zhou, Yan Luo et al.
· Frontiers in Physiology · 0 citations