Author

Huaxing Shen

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Open access Sep 2026

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

ABSTRACT Limited aqueous dispersibility and potential off‐target toxicity hinder the development and clinical translation of proteolysis‐targeting chimeras (PROTACs). Herein, a bioactive self‐delivering “Split Nano‐Assembly of Photosensitizers and Targeting Chimeras” (SNAP‐TAC) theranostic platform is developed to addr...

Shi-Qin Jian, Jia-Sha Wu, Fu-Sheng Xu et al. · Advancement of science · 0 citations

Jul 2026

Discovery of Stapled Peptide MYC Degrader with Potent In Vivo Activities for Triple-Negative Breast Cancer Therapy.

This study validates stapled peptide-based CMA degraders as a powerful strategy to target "undruggable" intracellular drivers, highlighting MAX-7 as a promising therapeutic lead.

Nan Zhang, Xin Li, Yunchen Xu et al. · Journal of Medicinal Chemist... · 0 citations