Author

Hua Zhang

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Open access Oct 2026

ZC3H14 phosphorylation is required for nuclear speckle assembly during zygotic splicing activation in mice.

Following zygotic genome activation (ZGA) in embryos, nuclear speckles, which are subnuclear domains where pre-mRNA undergoes splicing, are reassembled in a process called zygotic splicing activation (ZSA). ZSA is vital for early development, but its regulation is poorly understood. This study identifies the RNA-bindin...

Yang Wang, Hua Zhang, Zhe-Wei Hu et al. · EMBO Reports · 0 citations

Open access Aug 2026

Maternal PAN2 selectively maintains mRNA Poly(A) tail homeostasis to regulate RNA degradation during oocyte-to-early embryo transition in mice.

This study establishes maternal PAN2 as a critical regulator of poly(A) tail homeostasis, ensuring timely maternal mRNA clearance and proper ZGA, highlighting the stage-specific and tail-composition-dependent functions of the deadenylase cascade during the maternal-to-zygotic transition.

Xuan Wu, Hua Zhang, Yu-Ke Wu et al. · Science Bulletin · 0 citations

Open access Aug 2026

The RNA ac4C writer NAT10-dependent post-transcriptional regulations are prerequisites for zygotic splicing activation in mouse

It is demonstrated that the RNA ac 4 C writer NAT10 is essential for the post-transcriptional regulation of mouse zygotic splicing activation and provide valuable view for further exploration of the epigenetic mechanism during maternal-to-zygotic transition.

Wen-Jing Wang, Yu-Ke Wu, Yun-Wen Wu et al. · Cell Death & Disease · 0 citations