Author

Huan-Huan Wang

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Open access Sep 2026

M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis

ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage‐derived exosomes in DN progression remains largely unexplored. Methods THP‐1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extra...

Lei Li, Hong-Mei Liu, Yu Mao et al. · Journal of Diabetes Investig... · 0 citations

Open access Aug 2026

Empagliflozin attenuates AGE-BSA/high-glucose-induced inflammation in C2C12 myotubes associated with suppression of the RAGE/NF-κB pathway

Introduction Empagliflozin is an established sodium-glucose cotransporter 2 inhibitor with reported anti-inflammatory activity, but its effects on advanced glycation end product/high-glucose-induced inflammatory injury in skeletal muscle cells remain unclear. Methods A GEO-derived transcriptomic dataset from gastrocnem...

Xiao-Ying Zhang, Yu Mao, Jia-Xing Wu et al. · Frontiers in Endocrinology · 0 citations