Author

Huan-Huan Y. Wei

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Open access Sep 2026

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

ABSTRACT Deregulated alternative splicing (AS) is a hallmark of hepatocellular carcinoma (HCC), yet the specific splicing factors driving oncogenic programs remain largely uncharacterized. Here, we identify RNA‐binding motif protein 25 (RBM25) as a potent oncogenic driver that is overexpressed in HCC and correlates wit...

Wen-Jing Zhang, Li-Li Zhi, Tian Huang et al. · Advancement of science · 0 citations

Open access Aug 2026

Pan-cancer splicing landscape identifies that the alternative splicing of SLK regulates cancer metastasis.

Splicing dysregulation frequently occurs in cancers, yet the functional implications of most mis-spliced genes remain elusive. Through a comprehensive pan-cancer analysis of splicing dysregulation, we identified universally mis-spliced genes in cancers and were surprised to find their significant functional enrichment...

Yang Zhao, Yue Hu, Sishi Zhang et al. · Pharmacological Research · 0 citations