The cellular innovations underlying vertebrate gastrointestinal diversification remain largely unknown. Here, we constructed a single-cell and spatial transcriptomic atlas comprising nearly 1 million cells from 10 species, spanning 500 million years of vertebrate evolution. Analysis of conserved gene co-expression modu...
LucaCell, a sequence-centric foundation model that represents genes through pre-trained mRNA sequence embeddings rather than static gene annotations, is presented, showing that sequence-informed gene representation can improve the generalization of single-cell foundation models across species, data types, and predictiv...
Yan Sun, Yong He, Min-Si Ren et al.· bioRxiv· 0 citations
BACKGROUND
Cystic echinococcosis, caused by the tapeworm Echinococcus granulosus sensu stricto (ss), is a globally distributed, zoonotic disease that is recognised by WHO as a neglected tropical disease. Despite its clinical and economic importance, nuclear genomic variation in this parasite has not been systematically...
Liina Anijalg, Pasi K. Korhonen, Neil D. Young et al.· The Lancet Microbe· 0 citations
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