Huan Tang

A candidate HNRNPU–CHD2 RNA-processing axis in neurodevelopmental disease

Heterozygous loss-of-function variants in HNRNPU, which encodes a nuclear RNA-binding scaffold protein, cause a neurodevelopmental disorder with epilepsy, intellectual disability and brain malformations, but the programs that link HNRNPU dosage to neuronal dysfunction remain poorly defined. We depleted HNRNPU in Human...