Author

Huang-Fan Xie

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Review Open access Sep 2026

Stimuli-responsive materials in organ-on-a-chip systems: from dynamic microenvironment modelling to functional readout

Organ-on-a-chip (OoC) systems provide an in vitro platform for modelling tissue phenotypes and functions. Compared with conventional cell culture or animal testing, they allow dynamic responses to be monitored in a setting more closely aligned with human biology. By integrating platform materials, membrane-based bioint...

Chun-Mei Xian, Yuan-Yuan Wu, Bing-Qing Xie et al. · Frontiers in Bioengineering... · 0 citations

Open access Sep 2026

CDK8 regulates definitive endoderm commitment through cAMP-lysosomal homeostasis and neuroectodermal suppression

Definitive endoderm (DE) specification is essential for gastrointestinal and respiratory organogenesis, yet upstream regulators that integrate signaling pathways with metabolic and epigenetic cues remain poorly understood. Here, we identified cyclin-dependent kinase 8 (CDK8) as an important regulator of human DE co...

Chun-Mei Xian, A. Huang, Zheng Bao et al. · Cell Death & Disease · 0 citations