Author

Huayu Kang

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Open access Jul 2026

Neddylation-dependent CUL3-KLHL12 E3 ligase drives microglial oxidative stress and neuroinflammation in traumatic brain injury by targeting GCLM for degradation.

The findings characterize the Neddylation-CUL3-KLHL12-GCLM axis as a critical regulator of microglial redox homeostasis and highlight this pathway as a promising therapeutic target for TBI intervention.

Yu Ni, Yuan Liu, Xincheng Zhang et al. · Journal of Translational Med... · 0 citations