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Author

Huayue Li

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Open access Aug 2026

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

It is demonstrated that Spongosorites sp-derived bisindole alkaloid (R)-6’-debromohamacanthin B (RDB) exerts dual bacterium-directed and host-directed activities, simultaneously attenuating virulence and biofilm formation while reinforcing host defense and controlling pathological inflammation.

Dan-Dan Li, Hui-Yan Li, Wen-Bo Niu et al. · 0 citations

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