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Hubert M. Tse

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Open access Sep 2026

Protective IFIH1 variant reduces islet stress and dysfunction in a type 1 diabetes genetic background

Summary Genome-wide association studies have identified IFIH1, which encodes the double-stranded RNA sensor MDA5, as a type 1 diabetes (T1D) risk locus. The IFIH1 E627∗ variant is associated with protection from T1D, whereas A946T is associated with increased risk. To examine how these variants influence islet response...

Daniel A. Veronese-Paniagua, Cameron Banks, Kameron Bradley et al. · 0 citations

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