Design, robust synthesis, and anti-liver cancer activity of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives: In vitro, gene expression, DNA damage, and DNA fragmentation.
A novel series of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives tested as anticancer agents against a panel of cancer cell lines, and the mechanism of action of the most active compounds against liver cancer was explored through gene expression, DNA damage, and DNA fragmentati...