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It is shown that intracellular pAg accumulation can modulate binding of Vγ9Vδ2+ TCR in a BTN3A1-dependent manner, indicating the important role of TCR binding to BTN3A1 in pAg recognition.
Summary Background Human pregnancy presents a unique physiological state that allows for growth of an antigenically dissimilar foetus. The immune system plays a key role in establishing and maintaining successful pregnancy, yet detailed understanding of immunological responses in pregnancy is lacking. Methods We define...
Bispecific antibodies targeting both MR1-5-OP-RU and CD3 that drive broad T cell killing of bacterially infected cells as well as tumor cells treated with 5-OP-RU are engineered, providing evidence for immune redirection via MR1-targeting TCRm-based nanobodies.
It is demonstrated that γδ T cells are effective at tarlatamab (delta-like ligand 3 [DLL3]-CD3 bispecific T cell engager [BiTE])-redirected SCLC killing and that zoledronate can sensitize SCLC cells to γδ T cell-mediated killing.
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