Aug 2026
Burden of Stroke and Its Subtypes in Young Adults in China: A Systematic Analysis from 1990 to 2023 and Projections to 2050.
Fei-Hong Hu, Hai-Lin Lu, Hong Xu et al.
· Neuroepidemiology · 0 citations
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Aug 2026
Discovery of a novel 10-hydroxy-12-methyl-substituted evodiamine derivative with anti-hepatocellular carcinoma activity through multi-pathway modulation involving suppression of PKA/AKT signaling cascades and moderate Topo I inhibition.
Hepatocellular carcinoma (HCC) is a highly lethal malignancy with poor prognosis. The clinical benefits of small-molecule therapeutics represented by sorafenib remain limited, underscoring the urgent need to continuously invest in the discovery of novel anti-HCC lead compounds. In this study, structural optimization of...
Yan Peng, Zi-Xuan Li, Hanxuan Mo et al.
· European journal of medicina... · 0 citations