Deciphering the Genetic Underpinnings of Liver Cirrhosis–Heart Failure Comorbidity Through Multi-Omics: CRIM1 as a Key Endothelial Mediator
The co-occurrence of liver cirrhosis (LC) and heart failure (HF) poses considerable clinical challenges, yet the cellular and molecular determinants of this comorbidity remain poorly characterized. To address this, we developed an integrative multi-omics pipeline encompassing GWAS meta-analysis, gsMap-based spatial tra...