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Hui-Hui Wang

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Open access Aug 2026

Enantioselective Biohalogenation of Spiro-Epoxyoxindoles Enabled by Engineered Halohydrin Dehalogenases.

We herein describe a biocatalytic halogenation approach that harnesses the reverse dehalogenation reaction of halohydrin dehalogenases. Through the integration of enzyme screening and structure-guided protein engineering, a double mutant of HheC (T134S/W139M) was created for the enantioselective halogenation of spiro-e...

Hai-Xia Zhang, K. Lu, Xian Gao et al. · Angewandte Chemie · 0 citations