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Author

Hui-Jie Zhang

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Review Open access Oct 2026

Traditional Chinese Medicine Modulation of Macrophage Polarization in Inflammation Associated with Coronary Heart Disease: Mechanisms and Challenges

: Coronary heart disease (CHD) remains a leading cause of global mortality, with unresolved inflammation constituting a major residual risk after conventional therapies. Macrophage polarization, characterized by shifts between pro-inflammatory M1 and reparative M2 phenotypes, influences vascular inflammation, plaque st...

Shuai Wang, Dong-Shuai Zhang, Yan-Dan Yang et al. · 0 citations
Review Open access Aug 2026

IL-18 in atherosclerosis: context-dependent biology, human evidence, and translational challenges

Atherosclerosis is a chronic inflammatory disease shaped by interactions among vascular cells, innate immunity, adaptive immunity, and metabolic stress. Interleukin-18 (IL-18), an IL-1 superfamily cytokine activated predominantly downstream of inflammasomes, links vascular injury to type 1 immune responses. This struct...

Dong-Shuai Zhang, Shuai Wang, Yang Li et al. · 0 citations

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