Hui-Jing Zhang

A synergistic antifungal agent from Ligusticum chuanxiong: Total synthesis, biological evaluation, and mechanism of ligustrumdiol A.

Invasive fungal infections threaten immunocompromised patients, and the toxicity, resistance, and narrow spectrum of current therapies demand new agents. A chemical investigation of the medicinal plant Ligusticum chuanxiong led to the isolation of a rare pentyl-substituted cyclohexene derivative, ligustrumdiol A (LDA)....