Limited CYP1A2/3A4 activity in wild-type HepG2 cells can obscure hepatotoxic responses that require metabolic activation. We established matched CYP1A2/3A4-co-expressing and empty-vector (EV) HepG2 cells and profiled 81 compounds with six high-content imaging readouts and three extracellular injury biomarkers. Absolute...
Erin L. Li, Jing Long, Ting Yu et al.· Food and Chemical Toxicology· 0 citations
The total saponins from Celosiae Semen (TSCS) show hepatoprotective and lipid-lowering effects against metabolic dysfunction-associated steatotic liver disease (MASLD). However, their in vivo metabolic fate and holistic pharmacokinetic (PK) features remain largely uncharacterized. In this study, an integrated PK-marker...
Chun-Lu Liu, Lu-Lu Yang, Song Fan et al.· Journal of Pharmaceutical an...· 0 citations
Applying PRISM to CTCs from pancreatic cancer patients, a novel data analysis framework is introduced, including a 'Metastasis Potential Score' (MPS), to translate high-dimensional spectral data into a clinically relevant metric for risk stratification.
Yanrong Wen, Mengxiang Liu, Chun-Hui Liu et al.· ACS Sensors· 0 citations
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