Hui-Jun Yang

Efficient and Stereoselective Enzymatic Synthesis of Multisubstituted α , β -Diamino Acid

α,β-Diamino acids are privileged motifs present in numerous bioactive natural products and synthetic molecules, yet their asymmetric synthesis remains challenging and limited in scope. Herein, we repurpose l-threonine aldolases to catalyze a stereoselective intermolecular Mannich-type reaction, enabling the direct an...