Spica Prunellae attenuates ER stress via GRP78/IRE1α/JNK pathway in CCL4-induced acute liver injury in mice
Objective To evaluate the effects of Spica Prunellae (SP) on CCl4-induced acute liver injury (ALI) in mice and its regulation of the endoplasmic reticulum stress pathway. Methods In the toxicity test, ICR mice were administered SP decoction (2 g/kg, crude herb/mouse weight) by gavage for 10 days. Liver and kidney tissu...